Vitamin K2 Ingredient Has Good Stability When Formulated with Calcium and Other Mineral Salts, According to New Study
Gnosis S.p.A says that its VitaMK7 exhibited good stability when formulated with calcium and other mineral salts.
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A new stability study conducted by supplier Gnosis S.p.A (Milan) demonstrated that the company’s vitamin K2 ingredient, VitaMK7, is highly stable when formulated with the mineral salts calcium citrate, calcium carbonate, and arginine. In the 12-month stability study, VitaMK7 remained stable at percentages of 95%, 97%, and 91%, respectively, at the end of 12 months. The company says that VitaMK7 has good stability at room temperature after three years. In addition, the study found that VitaMK7 exhibited “remarkable assay recovery” of 93% after being exposed to short-term light for a period of 48 hours.
VitaMK7 is a natural vitamin K2 extract that is manufactured via a fermentation process using Bacillus subtilis. According to Gnosis, many synthetic MK7 and fermentation-derived MK7 ingredients are more likely to contain impurities. In addition, it says, the use of solvents can further degrade vitamin K2 ingredients. VitaMK7, meanwhile, is formulated with a “clean profile” without solvents and allergens, which the company says minimizes the cross-reactions with other ingredients and excipients used in formulation. “A pure and stable MK7 ingredient like VitaMK7 minimizes the cross-reactions with other ingredients/excipients included in a formulation for the whole shelf life of the product, and offer[s] extended warranty of stability,” the company says.
In this study, Gnosis examined VitaMK7’s stability when formulated with calcium citrate, calcium carbonate, and arginine. By the end of the 12-month study period, VitaMK7 was 95% stable when formulated with calcium citrate, 97% stable when formulated with calcium carbonate, and 91% stable when formulated with arginine. The company says the new data enables manufacturers to offer extended warranty of stability when formulating with VitaMK7.
The full study data can be viewed via a chart on the company’s website.
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