Now develops analytical method to test pesticide residue in challenging botanicals

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Now (Bloomingdale, IL) published a test method developed for the analysis of pesticide residues in botanicals that present a challenge when being analyzed by gas chromatography – tandem mass spectrometry (GC-MS/MS) due to concentration of the matrix during the extraction process. Although QuEChERS extraction paired with solid-phase extraction (SPE) is useful for routine analysis, certain extracts with greater matrix effects are still challenging such as standardized hawthorn extract powder.

Now scientists used C18E d-SPE cleanup in addition to the standard QuEChERS and SPE sample cleanup. The method modification reduced the total number of non-analyzable compounds (due to chromatographic interferences) from 35 to 19 and improved pesticide detection in hawthorn extract.

“This is yet another example of our commitment to science in the ongoing quest to ensure that our customers have access to the highest quality ingredients and products,” said Aaron Secrist, executive vice president of quality, R&D and operations for Now, in a press release. “The great work done by our scientists is invaluable not only to Now but to the greater industry as we make our research available to all. This type of work often times will be the launching board for others in the industry as they struggle with similar challenges. Now is proud to be a resource to the dietary supplement industry to help raise the bar with regards to quality and safety, and also to the greater analytical community at large.”

Now’s analytical pesticide team (Jerry Mueller, Camille Grigsby, and Carlos Parra) developed the method and presented the research at the North American Chemical Residue Workshop (NACRW) on 7/27/2021.