Landkind Pure Salidroside from Gnosis by Lesaffre shown to enhance exercise performance in new study

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In a December 10 press release, Gnosis by Lesaffre announced results from its study on its ingredient, Landkind Pure Salidroside, a fermented salidroside bioactive, which was launched earlier this year. The study, “Salidroside and exercise performance in healthy active young adults – an exploratory, randomized, double-blind, placebo-controlled study,” was published in the Journal of the International Society of Sports Nutrition in November 2024.

The 16-day study aimed to examine the short-term effects of Landkind Pure Salidroside on exercise. Fifty participants received either 30 mg twice daily of Landkind or placebo. Tests and assessments were completed for peak oxygen consumption (VO2), maximal strength, muscular endurance, and mood state evaluations, plus blood samples were taken to test for erythropoietin, myoglobin, and creatine kinase-MM.

As highlighted in the press release, significant results from the study include:

• Oxygen uptake was enhanced in the group supplemented with salidroside during high-intensity intermittent exercise.
• The salindroside group showed more stable mood than the placebo group, which also showed higher levels of inertia fatigue.

“Several dimensions of sports performance were positively influenced by dietary supplementation with salidroside, from cardiovascular fitness and aerobic endurance to recovery,” stated Florian Mourey, co-author of the study and Gnosis Substantiation Plan Manager, R&D, in the press release. “In addition, the results of this clinical study suggest a positive effect of salidroside in reducing muscle damage following resistance exercise and inhibiting a decline in high-intensity exercise performance.”

Salindroside was determined to be safe and well-tolerated. “After extensive peer review, we received extremely positive reviewer comments,” stated Neil Schwarz, PhD, Associate Professor at the University of South Alabama and first author of the study. “One stated that the study provides ‘extremely novel insights’ into several potential health and performance benefits of the synthesized salidroside.”

A compound from the Rhodiola rosea, Salindroside occurs in limited quantities in the plant. As rhodiola becomes more popular as an adaptogen and its supplies depleted, CITES (Convention on International Trade in Endangered Species) listed R. rosea as an endangered species. To isolate pure salindroside and bypass the need for harvesting the plant, Gnosis and Lesaffre Institute of Science and Technology teams employ a proprietary fermentation process.

"What we have with LANDKIND Pure Salidroside is truly unique in the industry," stated Nicole Lemus, Gnosis Director Americas, in the press release. "Our precision, proprietary fermentation process creates a sustainable, ethically sourced bioactive of Rhodiola with consistent purity and stability. Most importantly, it offers brand owners unmatched convenience and versatility for cutting-edge product development: with a lower dose requirement versus Rhodiola extracts, LANDKIND Pure Salidroside offers a proven base for innovative natural energy products with room for other targeted bioactives. It can also be a powerful but small-dose natural energy component that can be easily added to existing products. In either case, its pure format avoids the bulk and taste challenges of large Rhodiola doses.”

Additionally, Landkind Pure Salidroside is self-affirmed GRAS and third-party certified for kosher, halal, vegan, gluten-free, and non-GMO.

Reference

1. Schwarz NA.; Stratton MT.; Colquhoun RJ.; Manganti AM.; Sherbourne M.; Mourey F.; White CC.; Day H.; Dusseault MC.; Hudson GM.; Vickery CR.; Schachner HC.; Kasprzyk PG.; Weng J-K. Salidroside and exercise performance in healthy active young adults – an exploratory, randomized, double-blind, placebo-controlled study, Journal of the International Society of Sports Nutrition, 2024 DOI: 10.1080/15502783.2024.2433744