Curcumin C3 Complex May Reduce Oxidative Stress in Diabetes Patients

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Sabinsa (East Windsor, NJ) has shared new study results that suggest its Curcumin C3 Complex combined with its BioPerine piperine, a black pepper extract designed to enhance ingredient bioavailability, may offer antioxidant benefits to patients with type II diabetes. The study¹, published in Inflammopharmacology, is “the first clinical report on the impact of curcuminoid piperine supplementation on oxidative indices of subjects with [type II diabetes],” researchers reported.

The double-blind, placebo-controlled study included 118 subjects aged 18–65 with type II diabetes. For three months, subjects were randomized to consume either a placebo or a curcuminoid supplement containing 1000 mg/day of Curcumin C3 Complex and 10 mg/day of  BioPerine. Researchers measured serum total antioxidant capacity (TAC), superoxide dismutase (SOD) activities, and malondialdehyde (MDA) concentrations at both baseline and after the supplementation period.

Researchers found that  curcumin supplementation significantly elevated TAC and SOD activities, while also significantly reducing serum MDA levels compared with the placebo group. What's more, the results were found to remain statistically significant after adjusting for potential cofounders, such as baseline differences in fasting serum insulin and body mass index.

“Diminution of the well-marker of oxidative stress, MDA, as well as the increase in TAC and SOD, body's natural and most powerful anti-oxidant enzymes, are prized goals indicative of the body's response to undo the damage wreaked by hyperglycemia,” says Nagabhushanam Kalyanam, PhD, president of R&D for Sabinsa, in the study announcement. “The growing body of science indicates this combination can play a significant role in supporting the health of diabetes patients.” Kalyanam adds that Sabinsa plans to pursue this line of study further.

“The present results support an antioxidant effect of curcuminoids supplementation in patients with [type II diabetes], and call for future studies to assess the impact of these antioxidant effects on the occurrence of diabetic complications and cardiovascular endpoints,” researchers concluded.

References:

1. Panahi Y et al.,” Antioxidant effects of curcuminoids in patients with type 2 diabetes mellitus: a randomized controlled trial,” Inflammopharmacology, vol. 25, no. 1 (February, 2017): 25–31