Chr. Hansen, Caelus Health Collaborate on Probiotic for Metabolic Disease
Chr. Hansen intends to develop an advanced formulation of Caelus Health's CP-001 probiotic strain for upcoming phase II clinical studies.
Photo © iStockphoto.com/David Marchal
Chr. Hansen (Hørsholm, Denmark) and Caelus Health (Amsterdam) are teaming up to develop a “next generation” probiotic for the prevention and treatment of metabolic disease.
Caelus Health’s patented Eubacterium hallii CP-001 strain is at the center of the collaboration, which has shown potential at reducing insulin resistance in preclinical studies, according to a press release. E hallii CP-001 is currently in a phase I clinical study, but Chr. Hansen plans to take it a step further with the new deal.
“The objective of the collaboration between Chr. Hansen and Caelus Health is to develop a CP-001 product formulation that will allow for progression to a phase II clinical trial and a subsequent market introduction,” Chr. Hansen says.
Chr. Hansen will also develop pilot material and a production process for clinical trials which Caelus Health will then run, relating to the use of E hallii for “prevention and treatment of metabolic disease.”
“We are very pleased to announce this cooperation and are confident that Chr. Hansen has all the expertise and capabilities to develop an advanced formulation of CP-001, which we will further study in upcoming phase II clinical studies,” says Luc Sterkman, MD, CEO of Caelus. “This E. hallii-based product is the first of a series of microbiome-based products which Caelus plans to bring to the market.”
The agreement also marks an “important milestone” as the first of several human microbiome projects for Chr. Hansen, says Johan van Hylckama Vlieg, PhD, senior director of microbiome, Chr. Hansen.
“The collaboration with Caelus is in full alignment with our strategy to become the partner of choice for companies wanting to develop new generations of probiotic products and therapeutic microbes,” says van Hylckama Vlieg.
Read more:
Are Probiotics Moving Beyond Gut Health?
Herbal Ingredients Target Metabolic Syndrome
Blood Sugar Supplements: Postprandial Power
Michael Crane
Associate Editor
Nutritional Outlook Magazine
michael.crane@ubm.com
Kratom sees impressive sales growth despite its regulatory status and stigma
March 12th 2025Despite its controversy, kratom is a top-selling ingredient that consumers see value in. That said, brands need to work hard to demonstrate safety and quality of kratom products in the absence of legal regulatory status. Will kratom be able to overcome its stigma for even more growth and consumer acceptance?
DOJ asks Utah court to dismiss FTC lawsuit against Xlear Inc.
March 11th 2025On March 10, the DOJ and the defendant filed a stipulation to dismiss with prejudice the lawsuit in which each party agrees “to be responsible for its own costs and fees and agrees that no party shall be responsible to any other party for any fines, costs, fees, or penalties arising from this case.”
HHS announces efforts to eliminate independent conclusion of GRAS
Published: March 11th 2025 | Updated: March 11th 2025U.S. Department of Health and Human Services (HHS) Secretary, Robert F. Kennedy Jr., is directing the acting U.S. Food and Drug Administration’s (FDA) acting commissioner to explore rulemaking that would eliminate the independent conclusion of GRAS provision.
