Recent study shows that Magtein supports sleep quality and daytime functioning

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In a recently published study¹, supplementation with magnesium L-threonate (MgT, branded Magtein from Threotech) was shown to support sleep quality. In the study, 80 participants between the ages of 35 and 55 were randomized to receive 1 gram of MgT or placebo for 21 days. Researchers measured sleep and daily behaviors with standardized questionnaires, including the Insomnia Severity Index, Leeds Sleep Evaluation Questionnaire, and Restorative Sleep Questionnaire. For more objective measures, researchers used an Oura ring, a waterproof wearable multisensory device that quantifies daily physical activity and night-time sleep duration. It also estimates sleep stages.

Results showed that participants taking MgT maintained good sleep quality and daytime functioning while those taking placebo saw declines in those measures. Questionnaires showed that participants taking MgT saw significant improvements in behavior upon awakening, energy and daytime productivity, grouchiness, mood and mental alertness. Objective measures from the Oura ring showed that they saw significant improvements in deep sleep score, REM sleep score, light sleep time, activity and readiness parameters activity score, activity daily movement score, readiness score, readiness activity balance, and readiness sleep balance.

According to the researchers, these results are consistent with previous research that demonstrate in previous in vitro and animal models that MgT crossed the blood brain barrier to increase magnesium levels in the brain and neuronal cells. Previous research has also shown that the ingredient can support learning, memory, and stress.

“This study confirms numerous consumers reviews indicating restorative sleep when taking Magtein” said Jennifer Gu, PhD, vice president of research and development at ThreoTech and one of the study’s principal investigators, in a press release. “Given our growing understanding of brain bioavailable magnesium we hypothesized that Magtein would also have benefits for sleep. Our objectives were to investigate the impact of Magtein supplementation on sleep parameters, as well as on mood, daytime energy, and other related measurements.”

Reference

1. Hausenblas, H.A.; Lynch, T.; Hooper, S.; Shrestha, A.; Rosendale, D.; Gu, J. Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial. Sleep Medicine: X. 2024, 8, 100121. DOI: 10.1016/j.sleepx.2024.100121