Recent study provides evidence of healthy-aging benefits of Maypro’s Sirtmax

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A recent study¹, conducted by Tokiwa Phytochemical and the University of Tokyo, found that a proprietary extract of Kaempferia parviflora (Sirtmax from Maypro Industries; Purchase, NY), known as Thai black ginger, directly interacts with and stimulates sirtuin 1 (Sirt1). Sirt1, also known as NAD+-dependent deacetylase Sirt1, is a protein that has been shown in animal models to play a critical role in reducing the risk of age-related diseases such as type 2 diabetes, neurodegeneration, cancer, and Alzheimer’s disease. The protein drives many cellular activities such as energy metabolism, cell survival, DNA stability, inflammation, and circadian rhythm. Known as the longevity gene, the Sirt1 gene recharges mitochondria, says Maypro.

In the study, the researchers found that the proprietary extract stimulates Sirt1 activity by enhancing the binding affinity of Sirt1 with its substrate Ac-p53 peptide. The binding affinity was enhanced 8.2-fold by the Thai black ginger extract compared to 1.4 fold by resveratrol. The intracellular activity of Sirt1 was enhanced 1.7-fold by the Thai black ginger extract, compared to 1.4-fold by resveratrol.

“This new study is very exciting, and so it’s really an honor for us that we’re partnering with Tokiwa Phytyochemical to offer this research-validated and cutting-edge anti-aging proprietary ingredient to the U.S. marketplace,” said Dan Lifton, president of Maypro's Proprietary and Branded Ingredients division, in a press release. “With consumers increasingly concerned about aging and the associated chronic issues that can develop, we feel strongly that Sirtmax is poised for immense growth in a whole host of anti-aging applications. And we stand ready to work with customers on unique formulations using this proven proprietary extract.”

Sirtmax is non-GMO, gluten-free, dairy-free, and Kosher.

Reference

1. Zhang M et al. “Quercetin 3,5,7,3′,4′-pentamethyl ether from Kaempferia parviflora directly and effectively activates human SIRT1.” Communications Biology, vol. 4 (2021)