Proprietary turmeric extract from Nutriventia shows promising results in clinical trial on knee osteoarthritis patients

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In a March 31, 2025, press release, Nutriventia announced results from a recently published clinical trial¹ on the effects and safety of its turmeric extract TurmXTRA 60N for knee mobility. The extract contains 60% natural curcuminoids. The study, “Efficacy and Safety of a Novel Low-Dose Water-Dispersible Turmeric Extract in the Management of Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial,” was published in January 2025 in the Journal of Pain Research. As noted in the study, knee osteoarthritis is a degenerative joint disease with symptoms such as pain, inflammation, stiffness, and decreased mobility.

This study involved 139 participants ages 45-75 years with mild to moderate knee osteoarthritis (OA). The patients received either 250 mg capsule daily or placebo three months. Assessments were conducted at baseline and at 90 days.

Changes in pain were measured using the visual analog scale (VAS), knee function using the knee injury and osteoarthritis outcome score (KOOS) questionnaire, plus analysis of inflammatory biomarkers was done. Domains assessed in the KOOS were pain, symptoms, activities of daily living, function in sport and recreation, and knee-related quality of life.

Results at the end of the study include:

• The mean reduction in VAS score was significantly increased in the study group compared with the placebo group
• Improvements in pain were seen as early as seven days
• Higher mean KOOS scores were seen in the study group compared with the placebo
• Inflammatory biomarkers were also significantly reduced in the study group

"TurmXTRA 60N has consistently been studied in joint and muscle health for healthy individuals,” stated Rajat Mittal Shah, co-founder, Nutriventia, in the press release.“This marks our first clinical study in individuals with mild-to-moderate joint degradation, and we are encouraged by the significant improvements observed with just a small daily dose. TurmXTRA 60N was designed to reduce pill burden while delivering clinically meaningful benefits; these findings further validate its potential in supporting joint health."

Limitations to the study included the study population consisting of knee osteoarthritis only, and excluding patients with severe osteoarthritis. Future research was suggested to assess long-term effects of the supplement in symptom management.

Ultimately, the researchers concluded that the supplementation was safe and effective for relieving symptoms from knee osteoarthritis.

"These findings reinforce the potential of TurmXTRA 60N as a convenient and effective option for managing musculoskeletal health," stated Shefali Thanawala, BAMS, Nutriventia's general manager of medical science & research, nutraceuticals. “With positive results in mild to moderate knee discomfort, TurmXTRA 60N has shown promise as a potential agent for improving joint mobility and functionality, which is crucial for individuals across all age groups. Notably, these benefits have been observed consistently in clinical settings with a single daily dose, making it a convenient option that may enhance compliance."

“TurmXTRA, with its scientifically backed 250 mg single-dose formulation, offers a powerful adjunctive for individuals managing mild to moderate unilateral or bilateral knee osteoarthritis,” Thanawala added. “A 90-day regimen can provide effective support in alleviating symptoms, enhancing mobility, and improving quality of life, making it a valuable option for those seeking a natural approach to joint health.”

“Knee joint pain is very widespread, affecting older people, athletes and fitness enthusiasts, as well as those who are overweight and obese,” Shah added. “Once-daily TurmXTRA 60N turmeric is an attractive solution to help restore comfort for millions of people.”

Reference

1. Thanawala, S.; Shah, R.; Alluri, KV.; Bhupathiraju, K.; Prasad, N.; Agarwal, Y. Efficacy and Safety of a Novel Low-Dose Water-Dispersible Turmeric Extract in the Management of Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Journal of Pain Research. 2025. DOI: 10.2147/JPR.S501505.