Prebiotic ingredient reduced unfavorable metabolites while increasing healthy metabolites in recent in vitro study
A recent pre-clinical study found that a proprietary galactooligosaccharide (GOS) ingredient called Bimuno may help reduce unfavorable metabolites such as branched short chain fatty acids and ammonia, while increasing healthy metabolites such as short chain fatty acids, like butyrate.
Photo © AdobeStock.com/BillionPhotos.com
A recent pre-clinical study1 found that a proprietary galactooligosaccharide (GOS) ingredient called Bimuno may help reduce unfavorable metabolites such as branched short chain fatty acids (BSCFA) and ammonia, while increasing healthy metabolites such as short chain fatty acids (SCFA), like butyrate. Using a short-term colonic fermentation model, researchers found that colonic reactors inoculated with fecal samples supplemented with GOS saw decreased pH, and increased total SCFA, acetate, propionate, and butyrate, compared to untreated samples.
Samples treated with GOS also has lower BSCFA and ammonia levels compared to untreated samples. GOS-treated samples saw changes in microbiome composition as well. Specifically, GOS increased the relative abundance of Bifidobacterium longum, and significantly increased the absolute abundance of Bifidobacteriaceae, Lactobacillaceae, Bifidobacterium adolescentis, and Bifidobacterium ruminantium.
“Gut health science advances at speed, and with each new published study we get a stronger glimpse of where the potential lies. This new publication is a prime example of why the prebiotics category is growing and further underpins the solid body of evidence behind Bimuno GOS,” said Lucien Harthoorn, PhD, R&D director at Clasado Biosciences (Reading, UK), in a press release. Clasado Biosciences manufactures Bimuno GOS.
“Around the globe, we are seeing growing consumer appetite for prebiotics, as the importance of gut health comes to the forefront,” adds Harthoorn. “Of course, as consumers look for products they can trust, the scientific backing of prebiotic ingredients comes under the microscope. This latest study further strengthens the advantages of Bimuno GOS, and marks it as an effective choice for nutritional formulations.“
Reference
- Marzorati, M.; Ghyselinck, J.; Van den Abbeele, P.; Maruszak, A.; Harthoorn, L. Galactooligosaccharide (GOS) Reduces Branched Short-Chain Fatty Acids, Ammonium, and pH in a Short-Term Colonic Fermentation Model. Appl. Microbiol. 2023, 3(1): 90-103. DOI: 10.3390/applmicrobiol3010008
