PLT Health Solution's Bosewellia serrata extract granted updated license by Health Canada

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PLT Health Solutions (Morristown, NJ) has announced that Natural and Non-Prescription Health Products Directorate (NNPHD) of Health Canada has granted the company an updated license to market its AprèsFlex 5-Day Joint Support Ingredient in Canada. The patented low-dose extract of Boswellia serrata gum resin has been the subject of four randomized, double-blind human clinical trials, according to the company. A recent trial published in the journal Current Developments in Nutrition found that the extract supported joint function in participants with mild-to-moderate osteoarthritis.

In the study, 80 people between the ages of 40 and 75 were randomized to receive 100 mg of AprèsFlex or placebo for 180 days. Researchers assessed joint pain, stiffness, and functional mobility using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Visual Analog Scale (VAS), Lequesne’s Functional Index (LFI), Six-Minute Walk Test (SMWT), and Stair Climb Test (SCT) at days 30, 60, 120, and 180. They also used magnetic resonance imaging (MRI) to assess knee joint space and cartilage thickness at baseline and 180 days. Results showed that the extract significantly improved all measures of pain, stiffness, and mobility as well as knee joint space and cartilage thickness.

“With four gold-standard human clinical trials and counting, we are proud that AprèsFlex is one of the best substantiated joint health ingredients on the market today, powering some of the leading joint health consumer brands around the world,” said Seth Flowerman, president and CEO of PLT Health Solutions, in a press release. “The combination of fast acting experiential improvements in joint comfort with demonstrated long-term efficacy, and now with the newly demonstrated claims on cartilage health – both preservation and protection – offers the industry never-before available messaging opportunities for consumer products benefiting people of all ages – and all in a single, low daily dose of 100mg. Health Canada is well known for their rigorous scientific review process and the breadth and quality of claims permitted speaks to the high quality of science on this ingredient.”

The claims approved by Health Canada for AprèsFlex include:

• Provides long-term joint health benefits/support/pain relief in subjects suffering from mild to moderate osteoarthritis of the knee.
• Helps support improvements to joint comfort, stiffness and function over 6 months in persons with mild to moderate osteoarthritis of the knee.
• Helps to maintain joint space in subjects suffering from mild to moderate osteoarthritis of the knee.
• Helps to maintain cartilage in subjects suffering from mild to moderate osteoarthritis of the knee.
• Helps to maintain cartilage thickness/volume in subjects suffering from mild to moderate osteoarthritis of the knee.
• Helps to protect (knee) cartilage in subjects suffering from mild to moderate osteoarthritis of the knee.
• Helps to reduce cartilage breakdown in subjects suffering from mild to moderate osteoarthritis of the knee.
• Helps to reduce key biomarkers of cartilage breakdown in subjects suffering from mild to moderate osteoarthritis of the knee.
• Helps to improve joint function in subjects suffering from mild to moderate osteoarthritis of the knee.
• Helps to improve/increase mobility when walking and stair-climbing in subjects suffering from mild to moderate osteoarthritis of the knee.
• Helps to support joint function capacity when walking and stair-climbing in subjects suffering from mild to moderate osteoarthritis of the knee.
• Helps to protect against the deterioration of cartilage in persons with mild to moderate osteoarthritis of the knee.
• A factor in maintaining healthy cartilage and/or joint health in persons with mild to moderate osteoarthritis of the knee.
• Helps protect against the deterioration of cartilage in persons with mild to moderate osteoarthritis of the knee and relieve joint pain associated with mild to moderate osteoarthritis of the knee.
• Helps to improve/increase mobility in those suffering from mild to moderate osteoarthritis of the knee.
• Helps reduce mild to moderate osteoarthritic knee joint pain when walking and climbing stairs.

Reference

1. Murphy, J.L.; Salter, D.; Aurora, D.; Somepalli, R.R.; Brijesh, K. A Standardized Boswellia serrata Gum Extract Promotes Chondroprotection and Improves Knee Pain, Function, and Inflammation in Adults With Mild to Moderate Osteoarthritis. Curr Dev Nutr. 2024, 8 (2), 102214. DOI: 10.1016/j.cdnut.2024.102213