Patented Andrographis paniculata from HP Ingredients supports joint pain and stiffness in new study

Photo © Shutterstock.com/Sebastian Kaulitzki

A new study published in Phytotherapy Research, found that a patented extract of Andrographis paniculata (ParActin by HP Ingredients; Brandenton, FL) improved symptoms of joint discomfort in the knee. In the double-blind, randomized, placebo-controlled study, 103 adults with mild to moderate osteoarthritis in the knee were given either, 300 mg of the herb, 600 mg of the herb, or placebo daily for 84 days.

Researchers utilized the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) to assess pain in the subjects. Pain scores began showing a significant progressive reduction in the Andrographis groups starting at 28 days, compared to placebo, which did not show a significant reduction. WOMAC scores for joint stiffness also significantly decrease in the Andrographis group, starting at 28 days, compared to placebo. Scores for physical function also improved for subjects taking the herb, at days 56 and 84, compared to placebo. Both dosages of 300 mg and 600 mg were found to be efficacious, though one was not significantly better than the other.
 

References:

1. Hancke JL et al. “A double‐blind, randomized, placebo‐controlled study to assess the efficacy of Andrographis paniculata standardized extract (ParActin®) on pain reduction in subjects with knee osteoarthritis.” Phytotheraphy Research (2019): 1-11