Lipogen Going after Stress-Management Market with Phospholipid Combo

Photo © iStockphoto.com/BartekSzewczyk

Dubbing stress “today’s public enemy number-one,” Lipogen (Haifa, Israel) is now strengthening its campaign to gear its recently launched Lipogen PSPA ingredient to the stress-management dietary supplement market.

Lipogen PSPA is a combination of phosphatidylserine (PS) and phosphatidic acid (PA). Two human clinical trials attest to Lipogen PSPA’s benefits to brain health and stress management.

The first study¹, published in the journal Stress in 2004, was the first to confirm a “pronounced dampening effect" of Lipogen’s PS+PA daily on "the reactivity of the pituitary–adrenal axis to stress” in 80 subjects.

The second study², published in Lipids in Health and Disease in 2014, again found that the PS+PA combo lowered stress, leading the researchers to conclude that “in chronically stressed subjects, PAS 400 [featuring 400 mg PS and 400 mg PA] can be expected to buffer a hyper-responsivity of the [hypothalamus-pituitary-adrenal-axis] to acute stressors by normalizing cortisol responses.”

This year, Lipogen PSPA made its first U.S. debut in a stress-management supplement from Jarrow Formulas. “In launching the PS-PA Synergy [product], we’re presenting a new dietary supplement based on phospholipids to proactively support stress management at work and for students,” said Jarrow Formulas president and founder Jarrow Rogovin, in a press release.

Lipogen says it holds patents in the Untied States, the EU, and Canada to pave the way for its marketing partners.

Jennifer Grebow
Editor-in-Chief
Nutritional Outlook magazine
jennifer.grebow@ubm.com

References:

1. Hellhammer J et al., “Effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) on the endocrine and psychological responses to mental stress,” Stress, vol. 7, no. 2 (June 2004): 119-126
2. Hellhammer J et al., “A soy-based phosphatidylserine/phosphatidic acid complex (PAS) normalizes the stress reactivity of hypothalamus-pituitary-adrenal-axis in chronically stressed male subjects: a randomized, placebo-controlled study,” Lipids in Health and Disease. Published online July 31, 2014.