Citicoline research update

A vast array of substances and processes are required for a well-functioning brain. One such substance is citicoline. Citicoline can be synthesized by the body or obtained in pure dietary supplement form. Once the supplement is ingested, it undergoes a series of chemical transformations before being used in the synthesis and maintenance of brain cell membranes.¹

While the mechanisms by which citicoline works are not well understood, and despite negative press received on two large-scale trials on citicoline for ischemic stroke and traumatic brain injury,^2–3 scientists continue to investigate citicoline and the potential it may have to do some serious good when ingested as a dietary supplement.

Citicoline is actively sold in nootropics, formulas marketed for brain health, and as a standalone product. Many of these products feature Cognizin, a branded citicoline supplied by Kyowa Hakko USA (New York City) and for which there exists a sizable amount of ingredient-specific research.

Companies involved in the sale of citicoline products should stay afloat of the latest citicoline research. There’s a good amount of it, and we’ve broken down some of the latest findings.

References

• P Grieb. “Neuroprotective properties of citicoline: Facts, doubts, and unresolved issues.” CNS Drugs, vol. 28, no. 3 (2014): 185–193

• A Dávalos et al. “Citicoline in the treatment of acute ischaemic stroke: an international, randomized, multicenter, placebo-controlled study (ICTUS trial).” The Lancet, vol. 380, no. 9839 (July 28, 2012): 349–357

• RD Zafonte et al. “Effect of citicoline on functional and cognitive status among patients with traumatic brain injury: Citicoline Brain Injury Treatment Trial (COBRIT).” JAMA, vol. 308, no. 19 (November 21, 2012): 1993–2000

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